Accès ouvert
2026
preprint
OpenAlex
S Marina Casalino-Matsuda, Vijeeth Guggilla, Catherine A Gao, Kaitlyn E. DeMeulenaere et autres
Abstract Viral pneumonia is perpetuated by inflammatory circuits between activated T cells and monocyte-derived alveolar macrophages (MoAM). T cells and macrophages express ORAI1 and STIM1, which form calcium release-activated calcium (CRAC) channels that allow extracellular calcium entry in response to endoplasmic reticulum …
us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Nikolay S. Markov, Marcin Możejko, Vijeeth Guggilla, Małgorzata Łazęcka et autres
Pneumonia is the leading cause of death from infectious disease worldwide. The diagnosis and treatment of patients with pneumonia lag behind other major conditions, relying on syndromic definitions that lack molecular resolution and ignore underlying endotypes. We sought to test the hypothesis …
us, pl, de
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Catherine A. Gao, Nikolay S. Markov, Mengjia Kang, Luke V. Rasmussen et autres
Abstract Many analyses of critically ill patients focus on admission features and discharge outcomes, overlooking daily events and intercurrent complications. Pneumonia is a syndromic entity that is difficult to adjudicate outcomes without clinical expertise. Here, we examine clinical features on a day-by-day …
us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Alec Peltekian, Wan-Ting Liao, Vijeeth Guggilla, Nikolay S. Markov et autres
Purpose: Ventilator-associated pneumonia (VAP) remains one of the most serious hospital-acquired infections in the intensive care unit (ICU), with high morbidity and mortality. Early identification of patients at risk for developing VAP could enable timely diagnostics and intervention. However, current clinical tools …
us, fr
(code pays fourni par la source)