Structure‐Guided Engineering of 3D8 scFv Enhances Stability and Antiviral Potential
Kwang-ji Oh, Mee‐Hyang Jeon, Quynh Xuan Thi Luong, Won‐Kyu Lee et autres
The instability of recombinant antibody fragments hinders their therapeutic development. Single-chain variable fragment 3D8 (3D8 scFv), which possesses nucleic acid-hydrolyzing activity, exhibits broad-spectrum antiviral potential; however, its low solubility, rapid aggregation, and inconsistent production restrict its clinical application. Therefore, we used structure-based …
kr, vn (code pays fourni par la source)
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Biotechnology and Bioengineering