Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk
Aubrey K. Hubbard, Hélène Neyret‐Kahn, Martina Müller-Nurasiyd, Dominik Löw et autres
Abstract Ewing sarcoma (EwS) is a rare, aggressive pediatric malignancy driven by FET :: ETS family fusions ( EWSR1 :: FLI1 in >85% of cases) with no established environmental risk factors. To investigate germline predisposition, we analyzed 2,014 EwS cases and 10,525 …
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medRxiv