Seq-Scope-eXpanded: spatial omics beyond optical resolution
Angelo Anacleto, Weiqiu Cheng, Qianlu Feng, Anna Park et autres
Sequencing-based spatial transcriptomics (sST) enables transcriptome-wide gene expression mapping but falls short of reaching the optical resolution (200–300 nm) of imaging-based methods. Here, we present Seq-Scope-X (Seq-Scope-eXpanded), which empowers submicrometer-resolution Seq-Scope with tissue expansion to surpass this limitation. By physically enlarging tissues, …
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3 citations
Nature Communications