Shared PRAME epitopes are T-cell targets in NUT carcinoma
Jeffrey Lee Jensen, Sara K. Peterson, Maria J. Sambade, Jessica Alley et autres
Background NUT carcinoma is a rare but highly lethal solid tumor without an effective standard of care. NUT carcinoma is caused by bromodomain-containing NUTM1 fusion oncogenes, most commonly BRD4::NUTM1 . BRD4::NUTM1 recruits p300 to acetylate H3K27 forming expansive stretches of hyperacetylated chromatin …
us, au (code pays fourni par la source)
2 citations
Journal for ImmunoTherapy of Cancer