M Nakayama

Development and External Validation of a Machine Learning-Based Bleeding Risk Score for Patients Undergoing Percutaneous Coronary Intervention

Tatsuya Tokai, Masanobu Ishii, So Ikebe, Taishi Nakamura et autres

Background: Conventional bleeding risk scores after percutaneous coronary intervention (PCI) have limited discrimination and external validation, so we developed and validated a machine learning (ML)-based bleeding risk score using real-world data. Methods and Results: The primary outcome was major bleeding. In the …

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Does ECG-Based AI Detect Aortic Stenosis Beyond Conventional LVH Criteria? An Analysis of the CLIDAS Database

Takenobu Shimada, Satoshi Kodera, Shinnosuke Sawano, JingChuan Guan et autres

Abstract Background Aortic stenosis (AS) is a progressive valvular disease associated with poor prognosis once symptoms develop, yet routine echocardiographic screening is impractical. While artificial intelligence (AI)-based electrocardiogram (ECG) models have shown promise for AS detection, it remains unclear whether they primarily …

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Prognostic value of pretest probability of heart failure with preserved ejection fraction in patients with coronary artery disease: an insight from the CLIDAS-PCI database

Tomoaki Nishikawa, Shunsuke Tamaki, Kazuhisa Nishimura, Yasutaka Ihara et autres

Coronary artery disease (CAD) is a major risk factor for the development of heart failure (HF) with preserved ejection fraction (HFpEF) and is associated with increased mortality. However, an optimal strategy to screen for HFpEF among patients with CAD has not yet …

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Peak aortic jet velocity as a predictor of short- and long-term outcomes following percutaneous coronary intervention

Takamasa Iwai, Kensuke Takagi, Takeshi Kitai, Yasuhide Asaumi et autres

Background: Coronary artery disease (CAD) and aortic valve stenosis (AS) often coexist, with AS exacerbating myocardial ischemia and affecting prognosis. Aims: To investigate the prognostic impact of AS stratified by peak aortic jet velocity (AV-Vel) in patients undergoing PCI. Methods and results: …

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Retrospective observational analysis of prasugrel dosage after percutaneous coronary intervention using the Clinical Deep Data Accumulation System database

Yukio Hiroi, Yosuke Shimizu, Yukari Uemura, Iori Kajikawa et autres

Prasugrel reduces the recurrence of atherosclerotic cardiovascular disease and restenosis after percutaneous coronary intervention (PCI). However, its actual dosage in Japan has not been well studied. This study aimed to compare different prasugrel doses after PCI using retrospective data from the Clinical …

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Combined Triglyceride–High-density Lipoprotein Cholesterol Phenotypes and Cardiovascular Outcomes in Japanese Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Insights from Clinical Deep Data Accumulation System-PCI

Mitsukuni Kimura, Shunsuke Katsuki, Yasuhiro Nakano, Rissei Hino et autres

AIMS: Despite intensive lipid-lowering therapy, residual cardiovascular risk remains prevalent among patients with coronary artery disease. Although triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) metabolism are closely interrelated, their combined prognostic significance in secondary prevention remains unclear. METHODS: This study analyzed the …

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Subgroup-specific correlation between systolic blood pressure and mortality in patients with coronary artery disease undergoing percutaneous coronary intervention

Daisuke Sakamoto, Yohei Sotomi, Katsuki Okada, Shozo Konishi et autres

OBJECTIVES: The association between blood pressure (BP) and the mortality risk may vary depending on the comorbidities. This study was conducted to investigate the subgroup-specific correlation between systolic BP (SBP) and mortality in patients with coronary artery disease undergoing percutaneous coronary intervention …

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Prognostic value of pretest probability of heart failure with preserved ejection fraction in patients with coronary artery disease

T Nishikawa, Shunsuke Tamaki, K Nishimura, Osamu Yamaguchi et autres

Abstract Background Coronary artery disease (CAD) is a significant risk factor for heart failure (HF) with preserved ejection fraction (HFpEF) and is associated with increased mortality. However, an optimal diagnostic method to identify such patients remains undefined. The HFpEF-ABA score was recently …

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Efficacy and Safety of High-Intensity Statins in Japanese Patients After Percutaneous Coronary Intervention ― Insights From the Clinical Deep Data Accumulation System (CLIDAS®) ―

Tetsuya Matoba, Shunsuke Katsuki, Yasuhiro Nakano, Takuro Kawahara et autres

BACKGROUND: Lipid-lowering therapy with high-intensity statins has not been widely implemented in Japan for patients with coronary artery disease who undergo percutaneous coronary intervention (PCI). We examined the efficacy and safety of high-intensity statin therapy in a real-world setting. METHODS AND RESULTS: …

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Achievement of guideline-recommended target blood pressure is associated with reducing the risk of hemorrhagic and ischemic stroke in Japanese coronary artery disease patients -the CLIDAS study-

Yusuke Oba, Tomoyuki Kabutoya, Takahide Kohro, Yasushi Imai et autres

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Sex Differences in Long-Term Outcomes in Patients With Chronic Coronary Syndrome After Percutaneous Coronary Intervention ― Insights From a Japanese Real-World Database Using a Storage System ―

Naoyuki Akashi, Tetsuya Matoba, Takahide Kohro, Yusuke Oba et autres

BACKGROUND: Several studies have reported some sex differences in patients with coronary artery diseases. However, the results regarding long-term outcomes in patients with chronic coronary syndrome (CCS) are inconsistent. Therefore, the present study investigated sex differences in long-term outcomes in patients with …

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