Age-related GSS promoter methylation in BMSCs drives osteoporosis and the reversal by targeted GSH delivery
Pan Li, Zhuowen Liang, Xianyan Zeng, Runbo Lei et autres
Age-related osteoporosis arises from bone tissue with inadequate metabolic support for osteogenesis. We identified that DNA methylation-mediated suppression of glutathione synthetase (GSS) represents an upstream lesion limiting endogenous glutathione (GSH) synthesis and supply in aged bone, thereby constraining osteoblast differentiation. In turn, …
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