Bas Oldenburg

Univariate- and machine learning-based plasma metabolite signature differentiates PSC-IBD from IBD and is predicted to be driven by gut microbial changes

Joanna C. Wolthuis, Johannes P. D. Schultheiss, Stefanía Magnúsdóttir, Edwin C.A. Stigter et autres

INTRODUCTION: Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract comprising two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC). Up to 8% of patients with IBD also develop primary sclerosing cholangitis (PSC), characterised by …

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Ileocaecal resection versus infliximab for ileal Crohn's disease: retrospective 10-year follow-up of the LIR!C trial

Lotte Oldenburg, Anouck E G Haanappel, Mahsoem Ali, Carolijn Bosman et autres

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Distinct Effects of Autologous Hematopoietic Stem Cell Transplantation on T Cell Composition and Profile in Refractory Crohn’s Disease

Elise S Saager, Lisanne Lutter, Nofel Mahmmod, Eveline M. Delemarre et autres

BACKGROUND: Autologous hematopoietic stem cell transplantation (aHSCT) holds promise as a therapeutic strategy in patients with severe chronic inflammatory conditions that are refractory to conventional treatment, including Crohn's disease. The success of aHSCT is thought to be grounded in resetting the break …

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