Accès ouvert
2026
article
OpenAlex
Shanice Heidenreich, Jessica Faber, Markus Lorke, Dayana Herrera-Rios et autres
The treatment of brain metastases in malignant melanoma remains one of the major clinical challenges despite immuno-oncological and targeted therapies. Here, we revealed that successful colonization of the brain by melanoma cells is primarily determined by two complementary factors: (i) intrinsic phenotypic …
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Accès ouvert
2026
preprint
OpenAlex
René Krüger, Miguel Fuentes‐Chandía, Helly Atiya, Angeles De La Cruz et autres
Abstract Intravasation is the process by which cancer cells breach the physical boundaries of a primary tumor and enter blood or lymphatic vessels. In this work, MCF-7 breast cancer cells were cultured within polymer-based microcapsules (here referred to as artificial microtumors) to …
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2026
conference-paper
OpenAlex
Laura Wormser, VALERIE K. FRITZ, M Kappelmann-Fenzl, Nicole Rachinger et autres
RNA-interference (RNAi) therapeutics represent breakthrough discoveries, but their use in cancer remains limited due to hepatocyte-specific targeting. Cancer metastasis is regulated by complex crosstalk between tumour cells and niche-derived factors. However, the molecular mechanisms enabling metastatic seeding and outgrowth in the liver …
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