Diverse Ligands for Mycobacterial CYP124 Identified from Plant and Marine Compounds
Leonid Kaluzhskiy, Е.O. Yablokov, Tatsiana Varaksa, А. V. Grudo et autres
ABSTRACT Tuberculosis persists as a major global health threat, significantly exacerbated by the rise of drug-resistant strains. Cytochrome P450 of 124 family CYP124 from Mycobacterium tuberculosis (CYP124), implicated in host sterol metabolism and bacterial virulence, represents an emerging and promising therapeutic target. …
ru, by (code pays fourni par la source)
0 citations
bioRxiv (Cold Spring Harbor Laboratory)