Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues
Edmundo Torres-González, Barbara Arbeithuber, Nicholas Stoler, Marzia A. Cremona et autres
Mitochondrial function can be affected by mutations in mitochondrial DNA (mtDNA). However, detecting de novo mutations in mtDNA has been challenging due to its high copy number, particularly in germline cells, and the low accuracy of conventional next-generation sequencing technologies. Using highly …
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Molecular Biology and Evolution