A. L. Gintsburg

Structural basis of influenza A virus neutralization by broadly reactive single-domain antibody G2.3 recognizing glycosylated epitope within hemagglutinin stem domain

Igor O. Ilyasov, Daria V. Voronina, Timur N. Baymukhametov, Ivan I. Vorobiev et autres

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Sputnik V update: safety and neutralizing antibodies in healthy adults and adolescents

Inna V. Shuliakova, Daria M. Grousova, Anna A. Iliukhina, Alina S. Dzharullaeva et autres

Background: During the COVID-19 pandemic, adenoviral vector-based Sputnik V vaccine was used to vaccinate the civilian population of 74 countries worldwide. As part of laboratory monitoring of the effectiveness of the Sputnik V vaccine, a decrease in effectiveness was detected against Omicron …

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HIV-1 Genetic Diversity and Drug Resistance Mutation Profiles in Donetsk, Luhansk and Zaporizhzhia Regions

Anastasiia Antonova, Anatolii Vinokurov, Daria D. Kustova, Andrei A. Pochtovyi et autres

The first major HIV outbreak in the Eastern Europe and Central Asia (EECA) region was registered. Phylogeographic analysis revealed that the main exporters of the virus were Donetsk and Lugansk, from which most migration events occurred, and the predominant genetic variant in …

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Comparative analysis of three genetic constructs for delivery and expression of a modified single-domain antibody gene in rAAV

E. I. Ryabova, A. A. Derkaev, I. B. Esmagambetov, M. A. Dovgiy et autres

Objectives. To obtain and compare the efficiency of three recombinant adeno-associated virus (rAAV) variants expressing the gene of the modified single-domain antibody B11-Fc specific to botulinum toxin type A (BoNT/A): rAAV-DJ-CMV-B11-Fc, rAAV-DJ-CASI-B11-Fc, and scAAV-DJ-CMV-B11-Fc. Methods. The AAV-DJ Packaging System ( Cell Biolabs …

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