Transglutaminase 2 regulates vimentin-dependent proteostasis during macrophage activation
Yali Xu, Ting Su, Hricha Mishra, Naoshi Dohmae et autres
Sepsis-associated liver dysfunction is a life-threatening condition with a high mortality rate and no mechanism-based therapy. In this study, we identify the cross-linking enzyme transglutaminase 2 (TG2) as a driver of liver inflammation by activating macrophages in a mouse model of sepsis. …
cn, jp (code pays fourni par la source)