Mitochondrial DNA Variation in the Aging Human Cerebral Cortex and Cerebellum
Audrey A. Omidsalar, David R. Tyrpak, J. Andrew MacKay, Kelvin Yen et autres
Somatic differences in mitochondrial DNA (mtDNA) have been observed with aging and between brain regions for mutations, structural variation, and abundance, which are represented by single nucleotide variants (SNVs), large deletions, and copy number, respectively. We used bioinformatic methods to interrogate mtDNA …
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Aging Cell