Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Jérémy Dufau, Emeline Recazens, Laura Bottin, Camille Bergoglio et autres
In adipocytes, hormone-sensitive lipase (HSL) plays a key role in hydrolyzing triacylglycerols that are stored in lipid droplets. Contrary to the expected phenotype, HSL-deficient mice and humans exhibit lipodystrophy. Here, we show that HSL is also present in the adipocyte nucleus. Mouse …
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