Accès ouvert
2025
article
OpenAlex
Gemeng Zhang, Leland Barnard, Hugo Botha, Nick Corriveau‐Lecavalier et autres
BACKGROUND: Neuropathologic evaluation is essential for diagnosing and treating dementia, but definitive diagnoses is only available after post-mortem brain autopsy. Positron emission tomography (PET) offers a potential in vivo proxy for predicting neuropathology. This study proposes a semi-supervised learning (SSL) model using …
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Accès ouvert
2025
article
OpenAlex
Aivi T. Nguyen, Vijay K. Ramanan, Scott A. Przybelski, Ekaterina I. Hofrenning et autres
BACKGROUND: Cognitive resilience is the discrepancy in individuals with intermediate to high Alzheimer's disease neuropathologic change (ADNC) and normal cognition. Currently, the role of microglial activation in cognitive resilience is understudied. METHOD: In the MCSA brain bank, high-cognitively unimpaired (high-CU) participants were …
us
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Accès ouvert
2025
article
OpenAlex
Camilo Bermudez, Ekaterina I. Hofrenning, Jeffrey L. Gunter, Petrice M Cogswell et autres
BACKGROUND: Individuals with coexisting Alzheimer's disease (AD) and disorders of CSF dynamics such as normal-pressure hydrocephalus (NPH) have lower CSF Aβ42 levels, which can confound interpretation of AD CSF-biomarkers. However, little is known about how CSF dynamics influences plasma AD biomarkers. The …
us
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Accès ouvert
2025
article
OpenAlex
David N Jacobson, Mahathi Kandimalla, Seokbeen Lim, Emily S. Lundt et autres
BACKGROUND: Some data suggest that neuroinflammation may be associated with pro-inflammatory states in the body. Systemic, proinflammatory cytokines (TNFα, IL-1, IL-6, etc.) are produced by a variety of comorbidities. Neuroinflammation has been shown to be associated with the accumulation of amyloid in …
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