Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development
Sevgi Köstel Bal, Bernhard Ransmayr, Selin Sevinç, Candan İslamoğlu et autres
Introduction Biallelic mutations in MAP3K14 , encoding NF-κB-inducing kinase (NIK), disrupt non-canonical NF-κB signaling and lead to a rare inborn error of immunity marked by impaired lymphoid organ development, defective lymphocyte maturation, and susceptibility to recurrent infections. Hematopoietic stem cell transplantation (HSCT) …
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Frontiers in Immunology