Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome
Angela Mackay, Juraj Velcicky, Nina Gommermann, Henri Mattes et autres
Activation of the NLRP3 inflammasome in response to danger signals is a key innate immune mechanism and results in the production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) as well as pyroptotic cell death. Aberrant NLRP3 activation has been linked …
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37 citations
Journal of Medicinal Chemistry