Accès ouvert
2026
article
OpenAlex
Francesco Chiuso, Giuliana Giamundo, Emanuela Senatore, Laura Rinaldi et autres
The primary cilium is a sensory organelle present in all eukaryotic cells that acts as a signaling hub that receives, integrates and transmits signals carried out by extracellular stimuli, playing a fundamental role in cell behavior, development and tissue homeostasis. Genetic mutations …
it, fr
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Accès ouvert
2026
preprint
OpenAlex
Giuseppina Divisato, Stefano Tozza, Emanuela Cascone, E Polishchuk et autres
Biallelic mutations in the sorbitol dehydrogenase (SORD) gene have been identified as one of the most common causes of autosomal-recessive Charcot Marie Tooth disease type 2 (CMT2) and distal hereditary neuropathy, collectively referred to as SORD deficiency. These mutations result in loss …
it, cl
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Accès ouvert
2026
article
OpenAlex
Silvia Piscitelli, Emanuela Cascone, Chiara DˈAmbrosio, Giuseppina Divisato et autres
The transition of embryonic stem cells (ESCs) from a pluripotent state to lineage commitment is governed by complex regulatory mechanisms, including chromatin remodeling, as well as transcriptional and post-transcriptional processes. Recent studies have emphasized the interplay between these mechanisms, revealing intricate, multilayered …
it, gb
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Accès ouvert
2025
article
OpenAlex
Alessandro Emendato, Giuseppina Divisato, Emilia Giannino, Silvia Mansueto et autres
The misfolding of the human prion protein (hPrP) and the consequent self-assembly into insoluble amyloid fibrils are associated with neurodegenerative diseases known as transmissible spongiform encephalopathies (TSEs). In this study, we investigated the stability and aggregation behaviour of the folded C-terminal domain …
it
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