Ex vivo recapitulation of intramuscular mRNA vaccination with naïve and recall antigens using a human Lymphoid Follicle Chip platform
Yunhao Zhai, Min‐Wen Ku, Ka Yang, Aditya Patil et autres
Summary Predicting the efficacy and toxicity of intramuscular mRNA vaccines remains challenging. Here, we describe an ex vivo human cell-based model that replicates immune responses to lipid nanoparticle (LNP)-based mRNA vaccines that require intramuscular injection. Vaccines are administered into a biomimetic muscle …
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2 citations
bioRxiv (Cold Spring Harbor Laboratory)