334 Computational mapping of CAR-T cell exhaustion through single-cell perturbation screens
Li Wang, David DeTomaso, Ashley Cass, Julie Chow et autres
Background While CAR-T cell therapies in hematologic cancers have shown great promise, in solid tumors additional cell engineering will be required to overcome T cell exhaustion, insufficient persistence and the inhibitory tumor microenvironment. We have developed T cell engineering and automation platforms …
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Regular and Young Investigator Award Abstracts