Accès ouvert
2025
preprint
OpenAlex
J Li, Nilgun Tasdemir, Sofia Kyriazopoulou Panagiotopoulou, Sophie Xu et autres
A bstract Predicting cellular responses to therapeutics is a promising approach for novel target discovery. However, state-of-the-art computational models designed to predict perturbation effects struggle to generalize and outperform simple baselines. We present DINOcell, a weakly supervised framework that adapts self-distillation to …
us
(code pays fourni par la source)
Accès ouvert
2025
conference-paper
OpenAlex
Amaro Taylor‐Weiner, Sofia Kyriazopoulou Panagiotopoulou, Ashley Cass, David DeTomaso et autres
Background AI models have been developed to better understand disease through histology or protein structure, however these tools cannot model the impact of therapeutics on disease in a cellular context. AI cell models could simulate cellular responses to therapeutics, enabling exploration of …
us
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Li Wang, David DeTomaso, Ashley Cass, Julie Chow et autres
Background While CAR-T cell therapies in hematologic cancers have shown great promise, in solid tumors additional cell engineering will be required to overcome T cell exhaustion, insufficient persistence and the inhibitory tumor microenvironment. We have developed T cell engineering and automation platforms …
us
(code pays fourni par la source)