Xutao Deng

Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacy

Matthew S. Karafin, Aaron Issaian, Shaun Bevers, Julie A. Reisz et autres

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common human enzymopathy, affects 6% of the global population, yet its impact on blood storage and transfusion efficacy remains undefined. We integrated genome-metabolome-proteome analyses of 13,091 blood donors (362 G6PD SNPs), validated in a recalled cohort …

us, ca, ar (code pays fourni par la source)

Red blood cell urate levels are linked to hemolysis in vitro and post‐transfusion as a function of donor sex, population and genetic polymorphisms in SLC2A9 and ABCG2

Alicia Key, Eric J. Earley, Vassilis L. Tzounakas, Alkmini T. Anastasiadi et autres

BACKGROUND: Storage of packed red blood cells (RBCs) for transfusion leads to biochemical and morphological changes, increasing hemolysis risk. Urate levels in blood bags at donation contribute to the molecular heterogeneity and hemolytic propensity of stored RBCs. However, studies to date have …

us, gr, ca (code pays fourni par la source)

Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes

Travis Nemkov, Daniel Stephenson, Eric J. Earley, Gregory R Keele et autres

us, ca (code pays fourni par la source)