2026
article
OpenAlex
Rebecca Ronsley, Wenjun Huang, Ethan Rohlf, Kristy Seidel et autres
BACKGROUND: High-grade central nervous system (CNS) tumors carry a poor prognosis with limited curative options if first-line therapy fails. B7-H3 is expressed in many of these tumors, and chimeric antigen receptor (CAR) T cell therapy is an emerging immunotherapeutic strategy. METHODS: BrainChild-03 …
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Accès ouvert
2025
article
OpenAlex
Nicholas Alexander Vitanza, Rebecca J. Ronsley, Michelle Choe, Kristy D Seidel et autres
Abstract Diffuse intrinsic pontine glioma (DIPG) is a fatal central nervous system (CNS) tumor that confers a median survival of 11 months. As B7-H3 is expressed on pediatric CNS tumors, we conducted BrainChild-03, a single-center, dose-escalation phase 1 clinical trial of repetitive …
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Accès ouvert
2025
article
OpenAlex
You Cheng, Yingnan He, Karthik Kuduva Gopinath, Benjamin Billot et autres
The relationship between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegenerative effects is not fully understood. This study investigates neurodegeneration patterns across CSF Alzheimer's disease biomarker groups, the association of brain volumes with CSF amyloid and tau status and sex differences …
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Accès ouvert
2024
preprint
OpenAlex
Nicholas Alexander Vitanza, Rebecca J. Ronsley, Michelle Choe, Wenjun Huang et autres
us, es
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Accès ouvert
2024
conference-abstract
OpenAlex
Nicholas Alexander Vitanza, Rebecca J. Ronsley, Wenjuan Huang, Kristy D Seidel et autres
Abstract BACKGROUND BrainChild-03 is a first-in-human clinical trial that completed the phase 1 component of repeatedly dosed intraventricular B7-H3 CAR T cells to children with diffuse intrinsic pontine glioma (DIPG) without lymphodepleting chemotherapy. METHODS We report on BrainChild-03 Arm C, patients with …
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