Víctor M. Víctor

THU-038 Patients with chronic liver disease present elevated plasma levels of peptidylprolyl isomerase C associated with the degree of fibrosis

Cristina Benavides, Isabel Fuster‐Martínez, Ana M. Benedicto, Fernando Solano et autres

Gingival Inflammation Modulates NLRP3 Inflammasome Signalling in Peripheral Blood Mononuclear Cells of PCOS Patients: A Case-Control Study

Cecilia Fabiana Márquez‐Arrico, María Pelechá-Salvador, Meylin Fernández-Reyes, Francisco Javier Silvestre Donat et autres

Polycystic ovary syndrome (PCOS) is a complex condition associated with chronic inflammation and oxidative stress and is often linked to periodontal diseases. This study aimed to determine whether gingivitis modulates the NLRP3 inflammasome in peripheral blood mononuclear cells (PBMCs) from women with …

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Specific immune-inflammatory profiles and neurocognitive deficits predict illness trajectories in people with type 2 diabetes mellitus or psychiatric disorders

Joan Vicent Sánchez‐Ortí, Patricia Correa‐Ghisays, Vicent Balanzá‐Martínez, Gabriel Selva‐Vera et autres

Psychiatric disorders and type 2 diabetes mellitus (T2DM) are chronic conditions that are often comorbid with each other. Neurocognitive and functional impairments are associated with numerous clinical changes during the course of illness. Immune-inflammatory dysfunction is emerging as a critical factor in …

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Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity

Pau Soldevila-Matías, Joan Vicent Sánchez‐Ortí, Patricia Correa‐Ghisays, Vicent Balanzá‐Martínez et autres

INTRODUCTION: This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity …

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Cardiorespiratory Fitness is Associated with Metabolic, Inflammatory, and Oxidative Stress Biomarkers in Sedentary, Physically Active Individuals and Endurance Athletes

Omar A Hernández-López, Blanca Murillo Ortíz, Clara Luna-Marco, Julia Cacace et autres

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Autophagy and Mitophagy in Circulating Immune Cells of Women with Polycystic Ovary Syndrome: A Cardiovascular Perspective

María Pelechá-Salvador, Cecilia Fabiana Márquez‐Arrico, Meylin Fernández‐Reyes, Jonathan Hermenejildo et autres

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Exercise as a promoter of neurocognitive improvement in people with psychiatric disorders and comorbid obesity: A randomized controlled trial

Pau Soldevila-Matías, Joan Vicent Sánchez‐Ortí, Patricia Correa‐Ghisays, Vicent Balanzá‐Martínez et autres

INTRODUCTION: The psychiatric disorders and obesity comorbidity is related to neurocognitive impairment and inflammation. Exercise is crucial to improve and maintain healthy lifestyles. This randomized controlled trial tested the efficacy of aerobic exercise as promoter of neurocognitive improvement across psychiatric disorders with …

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Correction to: Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells

Maria Angeles Rodriguez Hernandez, Raquel Chapresto-Garzón, Miryam Cadenas, Elena Navarro‐Villarán et autres

In this article, the spheroid image obtained after 15 days of treatment of Hep3B with Cabozantinib was incorrectly duplicated from that obtained after 12 days. The new Fig. 1B shows the correct spheroid image at 15 days. The replacement does not change …

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Interference with mitochondrial function as part of the antifibrogenic effect of Rilpivirine: A step towards novel targets in hepatic stellate cell activation

Ana M. Benedicto, Federico Lucantoni, Isabel Fuster‐Martínez, Pedro Díaz-Pozo et autres

Activated hepatic stellate cells (aHSCs), the main perpetrators of liver fibrosis, are a promising therapeutic target in the treatment of chronic liver disease. During liver injury, HSCs transcend from a quiescent to a fibrotic phenotype, a process which involves major metabolic reprogramming …

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Systemic inflammation, oxidative damage and neurocognition predict telomere length in a transdiagnostic sample stratified by global DNA methylation levels

Joan Vicent Sánchez‐Ortí, Patricia Correa‐Ghisays, Vicent Balanzá‐Martínez, Diego Macías Saint-Gerons et autres

Abstract Epigenetic mechanisms contribute to the maintenance of both type 2 diabetes mellitus (T2DM) and psychiatric disorders. Emerging evidence suggests that molecular pathways and neurocognitive performance regulate epigenetic dynamics in these disorders. The current combined and transdiagnostic study investigated whether inflammatory, oxidative …

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THU-539 Exploring novel targets in hepatic stellate cell activation: interference with the mitochondrial function as part of the antifibrogenic effect of Rilpivirine

Ana M. Benedicto, Federico Lucantoni, Isabel Fuster‐Martínez, Cristina Benavides et autres

Inflammation and weight change related to neurocognitive and functional impairment in diabetes and psychiatric disorders

Joan Vicent Sánchez‐Ortí, Vicent Balanzá‐Martínez, Patricia Correa‐Ghisays, Gabriel Selva‐Vera et autres

INTRODUCTION: Obesity is a global pandemic associated with various cardio-metabolic and psychiatric disorders. Neurocognitive and functional deficits have been associated with several somatic and psychiatric disorders. Adiposity-related inflammation has recently emerged as a key risk factor for neurocognitive and functional impairments. This …

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