Thomas J. Sayers

CD8+ T–NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen–escape tumors

Roman V. Uzhachenko, Salvador González Ochoa, Thanigaivelan Kanagasabai, Harshana Rajakaruna et autres

Background and objective Tumor antigen–escape variants undermine immunotherapy by subverting lymphocyte effector functions and reshaping tumor–immune dynamics. It is essential to delineate functional interplay within immune networks during tumor progression. We investigated whether homeostatic crosstalk between CD8 + T cells and natural …

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Data from Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

Alan D. Brooks, Kristen M. Jacobsen, Wenqing Li, Anil Shanker et autres

Abstract Bortezomib (VELCADE) could sensitize certain human renal cell carcinoma (RCC) lines to the apoptotic effects of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). Analysis of seven human RCC showed a clear increase in the sensitivity of four of the RCC to TRAIL …

Data from Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

Alan D. Brooks, Kristen M. Jacobsen, Wenqing Li, Anil Shanker et autres

Abstract Bortezomib (VELCADE) could sensitize certain human renal cell carcinoma (RCC) lines to the apoptotic effects of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). Analysis of seven human RCC showed a clear increase in the sensitivity of four of the RCC to TRAIL …

Supplementary Data from Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

Alan D. Brooks, Kristen M. Jacobsen, Wenqing Li, Anil Shanker et autres

Supplementary Data from Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

Supplementary Data from Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

Alan D. Brooks, Kristen M. Jacobsen, Wenqing Li, Anil Shanker et autres

Supplementary Data from Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex

Data from Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, E. M. Kithsiri Wijeratne et autres

Abstract Screening for sensitizers of cancer cells to TRAIL-mediated apoptosis identified a natural product of the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), as a promising hit. In this study, we show that PCC was also able to sensitize melanoma and renal carcinoma …

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Supplementary Data from Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, E. M. Kithsiri Wijeratne et autres

Supplementary Materials & Methods, Supplementary Figures 1-10 with Figure Legends

Supplementary Data from Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, E. M. Kithsiri Wijeratne et autres

Supplementary Materials & Methods, Supplementary Figures 1-10 with Figure Legends

Data from Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, E. M. Kithsiri Wijeratne et autres

Abstract Screening for sensitizers of cancer cells to TRAIL-mediated apoptosis identified a natural product of the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), as a promising hit. In this study, we show that PCC was also able to sensitize melanoma and renal carcinoma …

Supplementary Figure 2 from Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity

Anil Shanker, Alan D. Brooks, Kristen M. Jacobsen, John W. Wine et autres

Supplementary Figure 2 from Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity

Supplementary Figure Legends 1-6 from Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity

Anil Shanker, Alan D. Brooks, Kristen M. Jacobsen, John W. Wine et autres

Supplementary Figure Legends 1-6 from Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity

Supplementary Figure 3 from Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity

Anil Shanker, Alan D. Brooks, Kristen M. Jacobsen, John W. Wine et autres

Supplementary Figure 3 from Antigen Presented by Tumors In vivo Determines the Nature of CD8+ T-Cell Cytotoxicity