A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease
M. Flint Beal, David Oakes, Ira Shoulson, Claire Henchcliffe et autres
IMPORTANCE: Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested …
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405 citations
JAMA Neurology