H. A. W. Neil

Effect of statins and ACE inhibitors on the metabolome in the Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT) cohort.

Beatrice Prampolini, Anthony Giton, Sofia Frassineti, Paul Benitez-Aguirre et autres

Effect of statins and ACE inhibitors on the metabolome in the Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT) cohort

Beatrice Prampolini, Anthony Giton, Sofia Frassineti, Paul Benitez-Aguirre et autres

Adolescence represents a pivotal period for the development of early diabetes-related vascular complications, primarily driven by chronic hyperglycemia and associated metabolic disturbances. Metabolomics provides a promising tool to identify biomarkers reflecting these early changes. The present study compared metabolomic profiles between adolescents …

it, gb, au, sg, ca (code pays fourni par la source)

P0490 A Gut Feeling? The role of faecal calprotectin in endoscopy referrals

F Hosty-Blaney, A McGettigan, A Adepbote, Anthony J. Corry et autres

Abstract Background Symptom-based triage systems can be unreliable in deciding which patients require colonoscopy. Faecal calprotectin (FC), is thus often used to guide referrals, as it rises in inflammatory bowel disease (IBD) due to neutrophilic infiltration of intestinal mucosa (1). Although its …

gb (code pays fourni par la source)

ASCEND-Eye

Emily L. Sammons, Georgina A. N. Buck, Louise J. Bowman, William M. Stevens et autres

PURPOSE: Preclinical studies support a protective role for aspirin in early diabetic retinopathy (DR), but the findings from randomized trials are limited. We present randomized evidence for the efficacy and safety of aspirin on DR outcomes. DESIGN: A substudy of the A …

gb (code pays fourni par la source)

Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort

Paul Benitez‐Aguirre, Maria Loredana Marcovecchio, Scott T. Chiesa, Maria E. Craig et autres

Abstract Aims/hypothesis We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retinopathy progression (3DR) independent of glycaemic control. Methods This …

au, gb, sg, ca (code pays fourni par la source)

Reduction in cardiovascular disease morbidity of men and women with familial hypercholesterolaemia (FH) associated with availability of high intensity statins: A cohort study using data from the UK Simon Broome Register linked with secondary care records

Barbara Iyen, Nadeem Qureshi, Paul J. Roderick, Nigel E. Capps et autres

gb (code pays fourni par la source)

Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes

Scott T. Chiesa, Maria Loredana Marcovecchio, Paul Benitez‐Aguirre, Fergus Cameron et autres

An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial and observational cohort study, we characterized the progression of vascular phenotypes throughout …

gb, au, ca (code pays fourni par la source)

Author response for "Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes"

Maria Loredana Marcovecchio, Marco Colombo, R. Neil Dalton, Paul McKeigue et autres

Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes

Elżbieta Niechciał, Carlo L. Acerini, Scott T. Chiesa, Tracey W. Stevens et autres

OBJECTIVE Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim was to assess adherence to ACE inhibitors …

pl, gb, au, ca (code pays fourni par la source)

A new strategy for vascular complications in young people with type 1 diabetes mellitus

Maria Loredana Marcovecchio, R. Neil Dalton, Denis Daneman, John Eric Deanfield et autres

gb, ca, au (code pays fourni par la source)

Coronary heart disease mortality in severe and non-severe familial hypercholesterolaemia: data from the uk simon broome fh register

Steve Eric Humphries, John A. Cooper, Mary Seed, Nigel E. Capps et autres

gb (code pays fourni par la source)

Renal and Cardiovascular Risk According to Tertiles of Urinary Albumin-to-Creatinine Ratio: The Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT)

Maria Loredana Marcovecchio, Scott T. Chiesa, Jane Armitage, Denis Daneman et autres

OBJECTIVE Baseline data from the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) indicated that tertiles of urinary albumin-to-creatinine ratios (ACRs) in the normal range at age 10–16 years are associated with risk markers for diabetic nephropathy (DN) and cardiovascular disease (CVD). …

gb, us, ca, au (code pays fourni par la source)