Thomas Anton Hinterleitner

Lifestyle factors associated with inflammatory bowel disease: data from the Swiss IBD cohort study

Severin A. Lautenschlager, Mamadou Pathé Barry, Gerhard Rogler, Luc Biedermann et autres

BACKGROUND: Various environmental risk factors have been associated with the pathogenesis of inflammatory bowel disease. In this study we aimed to identify lifestyle factors that affect the onset of Crohn's disease and ulcerative colitis. METHODS: 2294 patients from the Swiss IBD Cohort …

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The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients

Sebastian Bruno Ulrich Jordi, Brian Matthew Lang, Jacqueline Wyss, Bianca Auschra et autres

BACKGROUND: The bidirectional "gut-brain axis" has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While the influence of stress and depressive symptoms on IBD is well-characterized, the role of personality remains insufficiently investigated. METHODS: Personality was assessed in 1154 Swiss …

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Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients

Priyatharsan Yoganathan, Jean‐Benoît Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc et autres

BACKGROUND: Genetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn's Disease (CD). NLRP3 is part of the NLRP3-inflammasome that mediates the maturation of IL-1β and IL-18. Carrying the major …

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Depressive Symptoms Predict Clinical Recurrence of Inflammatory Bowel Disease

Sebastian Bruno Ulrich Jordi, Brian Matthew Lang, Bianca Auschra, Roland von Känel et autres

BACKGROUND: Inflammatory bowel disease (IBD) patients are at high risk for depression, and depression has been shown to affect disease course. We examined interrelations between depression, genetic risk factors for depression, and IBD flares. METHOD: In 1973 patients (1137 Crohn's disease, 836 …

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Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management

Martina Ledergerber, Brian Matthew Lang, Henriette Sophie Heinrich, Luc Biedermann et autres

Abstract Background Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have …

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Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis

Alexander Reinhard Siebenhüner, Jean‐Benoît Rossel, Philipp Schreiner, Matthias Butter et autres

BACKGROUND AND AIMS: Anxiety and depression are prevalent in patients with inflammatory bowel diseases (IBD), especially during IBD flares. IBD therapies can profoundly affect the mood of patients with IBD. We aimed to determine the long-term impact of anti-tumor necrosis factor (anti-TNF) …

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Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

Philipp Wuggenig, Berna Kaya, Hassan Bachir Melhem, C. Korcan Ayata et autres

Abstract Comprehensive development is critical for gut macrophages being essential for the intestinal immune system. However, the underlying mechanisms of macrophage development in the colon remain elusive. To investigate the function of branched-chain amino acids in the development of gut macrophages, an …

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Evaluating the Cost-Effectiveness of Early Compared with Late or No Biologic Treatment to Manage Crohn’s Disease using Real-World Data

Nadia Pillai, Judith Eva Lupatsch, Mark Dusheiko, Matthias M. Schwenkglenks et autres

BACKGROUND AND AIMS: We evaluated the cost-effectiveness of early [≤2 years after diagnosis] compared with late or no biologic initiation [starting biologics >2 years after diagnosis or no biologic use] for adults with Crohn's disease in Switzerland. METHODS: We developed a Markov …

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The Evolution of Health Care Utilisation and Costs for Inflammatory Bowel Disease Over Ten Years

Nadia Pillai, Mark Dusheiko, Michel H. Maillard, Gerhard Rogler et autres

BACKGROUND AND AIMS: Inflammatory bowel disease [IBD] places an economic strain on health systems due to expensive pharmaceutical therapy, risk of hospitalisation and surgery, and long-term monitoring. The evolving treatment guidelines advocate rapid scale-up to biologic agents in order to improve health …

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Cohort Profile Update: The Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS)

Valerie E. H. Pittet, Pierre Michetti, Christoph Mueller, Christian Braegger et autres

The SIBDCS was launched in November 2006 with the aim of enrolling and following patients with inflammatory bowel disease (IBD) throughout Switzerland. Our original sample included incident or prevalent cases, regularly treated in Switzerland, aged 2 and over. Patients were included through …

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Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study

Laura Renz, Nicolas Fournier, Jean‐Benoît Rossel, Matthias Butter et autres

BACKGROUND: The knowledge about risk factors for the onset of uveitis manifestations in patients with inflammatory bowel disease (IBD) is still limited. Here, we aimed to provide an overview of the clinical factors associated with the onset of uveitis in the Swiss …

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Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals

Valerie E. H. Pittet, Michel H. Maillard, Thomas Simonson, Nicolas Fournier et autres

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