O L Lopez

Intersections of sex and neighborhood disadvantage on Alzheimer's disease pathology

Alexandria C. Reese, Sarah K. Royse, Beth E. Snitz, Nirupama Natarajan et autres

BACKGROUND: Differences in Alzheimer's disease (AD) biomarkers have been reported by sex, but their intersection with neighborhood disadvantage is not understood. METHOD: C-PiB SUVR. Our vascular (V) measure was lobar unhealthy white matter connectivity (UWMC), a novel measure indicating the proportion of …

us, ca (code pays fourni par la source)

Synergistic effects of GFAP with TNFR1 and TNFR2 on conversion to AD dementia and overall survival across the Alzheimer’s disease spectrum

Laura Alejandra Ramirez Tirado, Ann D Cohen, C. Elizabeth Shaaban, Cristy Matan et autres

BACKGROUND: We recently reported synergistic effects of TNFR1 and TNFR2 with astrogliosis resulting in greater vascular burden and neurodegeneration, particularly in Aβ+ participants. Here, we aimed to assess the interactions of peripheral inflammation and astrogliosis on incidence of AD dementia and mortality. …

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Synergistic effects of peripheral inflammation and neuroinflammation on amyloid, vascular, and neurodegeneration markers across the Alzheimer’s disease spectrum

Laura Alejandra Ramirez Tirado, Ann D Cohen, C. Elizabeth Shaaban, Cristy Matan et autres

BACKGROUND: Systemic inflammation and astrogliosis are relevant in Alzheimer's disease (AD). We evaluated whether peripheral inflammation has synergistic effects with astrogliosis on β-amyloid (Aβ), vascular, and neurodegeneration markers. METHOD: In the Ginkgo Evaluation of Memory Study, we evaluated the relationship between peripheral …

us, se (code pays fourni par la source)

Genome-wide association study of Alzheimer's disease with psychotic symptoms

Paul Hollingworth, Robert A. Sweet, Rebecca Sims, Denise Harold et autres

gb, us, ie (code pays fourni par la source)