Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein
Beatriz Perdiguero, Alexandra Hauser, Carmen Gómez, David Peterhoff et autres
Introduction: The generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble, prefusion-stabilized, close-to-native, glycan-engineered clade C gp140 envelope (Env) trimers (sC23v4 KIKO and ConCv5 KIKO) for optimal display on …
es, de, at, ch, fr (code pays fourni par la source)
3 citations
Frontiers in Immunology