Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid
Maxwell Chirehwa, Helen McIlleron, Lubbe Wiesner, Dissou Affolabi et autres
Objectives: To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, and assess the effects of efavirenz co-administration and a 50% increase in the dose of rifampicin on the pharmacokinetic parameters of isoniazid and acetyl-isoniazid. Methods: TB/HIV-coinfected patients participating in the …
Afrique du Sud, Bénin, Guinée, gb, ch (code pays fourni par la source)
31 citations
Journal of Antimicrobial Chemotherapy