John Connell

Association mapping of wheat distinctness, uniformity, and stability traits identifies evidence of TaDof-B copy number variation associated with stem pith thickness

B. G. Love, Pauline Bansept-Basler, Tobias Barber, James A Bedford et autres

For new varieties to be sold, they must first pass assessment using a set of phenotypic criteria that test for distinctness, uniformity, and stability (DUS) and which serve as the basis for the awarding of plant breeders’ rights. The objective of this …

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Identification of hypertension subtypes using microRNA profiles and machine learning

Smarti Reel, Parminder Singh Reel, Josie Van Kralingen, Casper K. Larsen et autres

OBJECTIVE: Hypertension is a major cardiovascular risk factor affecting about 1 in 3 adults. Although the majority of hypertension cases (∼90%) are classified as "primary hypertension" (PHT), endocrine hypertension (EHT) accounts for ∼10% of cases and is caused by underlying conditions such …

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Fabrication of Solid-State Li-S Battery Components for Electric Aviation

Donald A. Dornbusch, Rocco P. Viggiano, Yi Lin, James T. Wu et autres

The development of high-energy, high-safety, and high-power batteries beyond electric automobile requirements is vital for future electric aviation applications. The transition to non-volatile solid-state electrolytes (SSE) promises many advantages over traditional flammable liquid electrolytes, and may also be an enabling technology for …

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HPB P68 Multimetric MRI detects improved quality of the future liver remnant post-dual vein embolization – a novel finding

Senthil Sundaravadanan, Fenella K.S. Welsh, Pulkit Sethi, Ben Cresswell et autres

Abstract Background Optimisation of the future liver remnant (FLR) is crucial to the safety of extended liver resections. This study aimed to assess volume and quality of the FLR pre- and post-dual vein embolisation (DVE) by MRI, in patients with insufficient FLR, …

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Design Considerations for Practical Li-S Battery Components for Electric Aviation

Donald A. Dornbusch, Rocco P. Viggiano, James T. Wu, Lin Yi et autres

The development of high-energy, high-safety, and high-power batteries beyond electric automobile requirements is vital for future electric aviation applications. The transition to non-volatile solid-state electrolytes (SSE) promises many advantages over traditional flammable liquid electrolytes and may also be an enabling technology for …

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Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran, Elena V. Feofanova, Najim Lahrouchi, Ioanna Ntalla et autres

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran, Elena V. Feofanova, Najim Lahrouchi, Ioanna Ntalla et autres

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) …

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Common variants near MC4R are associated with fat mass, weight and risk of obesity

J. Beckmann, Murielle Bochud, Subhajyoti De, Christian Dina et autres

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 × 10−6) mapped 188 kb downstream of MC4R …

Quantitative magnetic resonance imaging predicts individual future liver performance after liver reception for cancer

Damian J. Mole, Jonathan Fallowfield, Fenella K.S. Welsh, A. Sherif et autres

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Lisa de las Fuentes, Raymond Noordam, Thomas W. Winkler, Mary F. Feitosa et autres

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, …

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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Markku Laakso, Marcus E. Kleber, Yun Kyoung Kim, Peter E. H. Schwarz et autres

To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified …

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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Reedik Mägi, George Dedoussis, Therese Ohlsson, Philippe Frossard et autres

High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants …

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