Accès ouvert
2026
preprint
OpenAlex
Marius Messemaker, Connor A. Richterich, Jule Wenner, Yiting Ma et autres
Abstract Tumors contain a mixture of T cells with bystander reactivities and reactivities towards di7erent, frequently patient-specific, cancer (neo)antigens. The one-step identification of highly active TCR– antigen pairs in human tumors would be valuable, both as a monitoring tool and to boost …
nl, us, ch
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Kelly Boelaars, Ernesto Rodríguez, Zowi R. Huinen, Chang Liu et autres
Despite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor microenvironment, which is characterized by the abundance of cancer-associated fibroblasts (CAFs). Once identified, CAF-mediated immune inhibitory mechanisms could be exploited for cancer immunotherapy. Siglec receptors …
nl, us, it, ca
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kelly Boelaars, Laura Goossens-Kruijssen, Di Wang, Charlotte M. de Winde et autres
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful. PDAC is characterized by a desmoplastic, hypoxic and highly immunosuppressive tumor microenvironment …
nl
(code pays fourni par la source)