Mzwandile Erasmus

Blood transcriptomic signatures in children with tuberculosis in a treatment-shortening trial

James A. Seddon, Vanessa Mwebaza Muwanga, Claire Dunican, Simon C. Mendelsohn et autres

gb, Afrique du Sud (code pays fourni par la source)

Blood transcriptomic signatures in children with tuberculosis in a treatment-shortening trial: Public, subject-level signature scores, RT-qPCR data, and metadata

Vanessa Muwanga, Claire Dunican, Simon C. Mendelsohn, Ortensia Vito et autres

The SHINE trial demonstrated that 4 months of treatment was non-inferior to 6 months for children with non-severe tuberculosis drug-susceptible (DS-TB) as assessed on chest radiograph. However, the optimal duration likely varies between individuals. In the sub-study, an evaluation of blood transcriptomic …

Afrique du Sud, gb (code pays fourni par la source)

Blood transcriptomic signatures in children with tuberculosis in a treatment-shortening trial: Public, subject-level signature scores, RT-qPCR data, and metadata

Vanessa Muwanga, Claire Dunican, Simon C. Mendelsohn, Ortensia Vito et autres

The SHINE trial demonstrated that 4 months of treatment was non-inferior to 6 months for children with non-severe tuberculosis drug-susceptible (DS-TB) as assessed on chest radiograph. However, the optimal duration likely varies between individuals. In the sub-study, an evaluation of blood transcriptomic …

Afrique du Sud, gb (code pays fourni par la source)

Blood transcriptomic signatures predict poor outcomes in drug-susceptible pulmonary tuberculosis in Brazil

Simon C Mendelsohn, B. C. O. P. Andrade, Mariana Araújo-Pereira, Gustavo Amorim et autres

RATIONALE: Non-sputum biomarkers to monitor tuberculosis treatment and predict poor outcomes are lacking. OBJECTIVES: To evaluate host-blood transcriptomic signatures for treatment monitoring and prognosis of death, treatment failure, and recurrence in adults with pulmonary tuberculosis. METHODS: Adults with culture-confirmed, drug-susceptible pulmonary tuberculosis …

Afrique du Sud, br, us (code pays fourni par la source)

Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in Brazil

Simon C. Mendelsohn, Bruno Andrade, Mariana Araujo-Pereira, Gustavo Amorim et autres

OverviewThis is a public, subject-level dataset containing key variables necessary to reconstruct the study findings. A data dictionary is also provided in the README file. This dataset includes all available StandardBiotools Biomark HD microfluidic RT-qPCR data and transcriptomic signature scores for a …

Afrique du Sud (code pays fourni par la source)

Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in Brazil

Simon C. Mendelsohn, Bruno Andrade, Mariana Araujo-Pereira, Gustavo Amorim et autres

OverviewThis is a public, subject-level dataset containing key variables necessary to reconstruct the study findings. A data dictionary is also provided in the README file. This dataset includes all available StandardBiotools Biomark HD microfluidic RT-qPCR data and transcriptomic signature scores for a …

Afrique du Sud (code pays fourni par la source)

Comparison of automated and manual mRNA enrichment to automated rRNA depletion for whole-blood RNA-sequencing

Denis Awany, Helgard Claassen, Nadia Carstens, Simon C. Mendelsohn et autres

RNA sequencing libraries are typically processed before sequencing. We compared the performance of automated mRNA enrichment (autoE) and manual mRNA enrichment (manE) with globin depletion, and automated rRNA depletion (autoD) with globin depletion prior to sequencing. PAXgene tubes from 21 people living …

Afrique du Sud, gb, us (code pays fourni par la source)

Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in Brazil

Simon C. Mendelsohn, Bruno B. Andrade, Mariana Araújo‐Pereira, Gustavo Amorim et autres

Background: Non-sputum biomarkers to monitor tuberculosis (TB) treatment and predict poor outcomes are lacking. We evaluated host-blood transcriptomic signatures for treatment monitoring and prognosis (death, treatment failure, recurrence) in adults with pulmonary TB. Methods: Adults with culture-confirmed, drug-susceptible pulmonary TB were enrolled …

Afrique du Sud, br, us, jp (code pays fourni par la source)

Immunogenicity, safety, and efficacy of the vaccine H56:IC31 in reducing the rate of tuberculosis disease recurrence in HIV-negative adults successfully treated for drug-susceptible pulmonary tuberculosis: a double-blind, randomised, placebo-controlled, phase 2b trial

Álvaro H. Borges, Thomas J. Scriba, Elisa Nemes, Andrea Maurizio Cabibbe et autres

dk, Afrique du Sud, it, gb, Tanzanie, ch, us (code pays fourni par la source)

Blood transcriptomic signatures for symptomatic tuberculosis in an African multicohort study

Vanessa Mwebaza Muwanga, Simon C. Mendelsohn, Vinzeigh Leukes, Kim Stanley et autres

BACKGROUND: other respiratory diseases (ORD). METHODS: As part of a nested case-control study, individuals presenting with respiratory symptoms at primary healthcare clinics in Ethiopia, Malawi, Namibia, Uganda, South Africa and The Gambia were enrolled. TB was diagnosed based on clinical, microbiological and …

Afrique du Sud (code pays fourni par la source)

Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil

Simon C. Mendelsohn, Bruno B. Andrade, Stanley Kimbung Mbandi, Alice M S Andrade et autres

BACKGROUND: Approximately 5% of people infected with Mycobacterium tuberculosis progress to tuberculosis (TB) disease without preventive therapy. There is a need for a prognostic test to identify those at highest risk of incident TB so that therapy can be targeted. We evaluated …

Afrique du Sud, br, us, ch (code pays fourni par la source)

Diagnostic Performance of Host Blood Transcriptomic Signatures for Pulmonary Tuberculosis in a Multi-Cohort Study of Symptomatic Patients in Africa

Vanessa Mwebaza Muwanga, Simon C. Mendelsohn, Vinzeigh Leukes, Kim Stanley et autres

Afrique du Sud (code pays fourni par la source)