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2025
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OpenAlex
Carsten A. Wagner, Isabelle Frey‐Wagner, Alberto Ortíz, Robert J. Unwin et autres
Cognitive decline is frequently seen in patients with chronic kidney disease (CKD). The causes of cognitive decline in these patients are likely to be multifactorial, including vascular disease, uraemic toxins, blood-brain barrier leakage, and metabolic and endocrine changes. Gut dysbiosis is common …
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2025
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OpenAlex
Alexandre Andrade, Maie Bachmann, Mickaël Bobot, Annette Bruchfeld et autres
Chronic kidney disease is associated with cognitive impairment although the underlying mechanisms are still not fully understood. Characterization and efficient monitoring of the cognitive impact of kidney disease and ensuing therapies are critical for the accurate clinical management of patients. A vast …
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2025
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OpenAlex
Marion Pépin, Konstantinos Giannakou, Hélène Levassort, Ana Farinha et autres
Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review the mutual consequences of CKD and CI on health outcomes and care …
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2025
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OpenAlex
Carmine Zoccali, Francesca Mallamaci, Carsten A. Wagner, Robert J. Unwin et autres
Chronic kidney disease (CKD) is commonly accompanied by cognitive dysfunction and dementia, which, in turn, increase the risk of hospitalization, cardiovascular events and death. Over the last 30 years, only four studies focused on genetic markers of cognitive impairment in CKD and …
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2025
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OpenAlex
Jolanta Małyszko, Aleksandra Golenia, Michele Farisco, Vincenzina Lo Re et autres
Chronic kidney disease affects almost all of the organs. Recently, more attention has been paid to the kidney and the central nervous system connections. In patients on kidney replacement therapy, including kidney transplantation, there is an increased prevalence of cognitive impairment, and …
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2025
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OpenAlex
Giovambattista Capasso, Robert J. Unwin, Alexandre Andrade, Mustafa Arici et autres
Cognitive impairment (CI) is a growing concern among patients with chronic kidney disease (CKD), since its prevalence increases with declining kidney function. This underscores the need to understand better and address the cognitive challenges in this patient population. To tackle this, the …
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2025
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OpenAlex
Mariadelina Simeoni, Michele M. Mulholland, Biruh Workeneh, Anna Capasso et autres
Cancer and kidney diseases (KD) intersect in many ways resulting in worse outcomes. Both conditions are correlated with cognitive impairment, which can be exacerbated in cancer patients by known effects of many antineoplastic drugs on cognition, leading to a phenomenon known as …
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2025
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OpenAlex
Hong Xu, Maria Eriksdotter, Gaye Hafez, Sumonto Mitra et autres
Cholinergic synapses are widespread throughout the human central nervous system. Their high density in the thalamus, neocortex, limbic system and striatum suggests that cholinergic transmission plays a vital role in memory, attention, learning and other higher cognitive functions. As a result, the …
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2024
article
OpenAlex
Carmine Zoccali, Francesca Mallamaci, Kerry Rosenberg, Robert J. Unwin et autres
Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed by both CKD and cognitive impairment. CKD affects approximately 10-15% of the adult population, with higher prevalence in the elderly, who …
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2024
article
OpenAlex
Carsten A. Wagner, Ziad A. Massy, Marion Pépin, Mickaël Bobot et autres
Cognitive decline is common in patients with acute or chronic kidney disease. Several areas of brain function can be affected, including short- and long-term memory, attention and inhibitory control, sleep, mood, eating control and motor function. Cognitive decline in kidney disease shares …
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2024
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OpenAlex
Davide Bolignano, Mariadelina Simeoni, Gaye Hafez, Marion Pépin et autres
Cognitive impairment is a prevalent and debilitating complication in patients with chronic kidney disease (CKD). This position paper, developed by the Cognitive Decline in Nephro-Neurology: European Cooperative Target network, provides guidance on the epidemiology, risk factors, pathophysiology, diagnosis and clinical management of …
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