Accès ouvert
2026
article
OpenAlex
Lisa Le Scouarnec, Vincent Bouteloup, Timothy Daly, Vincent Planche et autres
Abnormal brain accumulation of amyloid-β peptides, represents one of the earliest biological indicators of Alzheimer’s disease (AD) risk. Estimation on amyloid positivity (A + ) prevalence among older adults without dementia are needed to assess the epidemiological impact of AD diagnosis solely …
fr
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Accès ouvert
2026
article
OpenAlex
Vincent Bouteloup, Cécile Proust-Lima, Isabelle Pellegrin, Andréa Boizard-Moracchini et autres
BACKGROUND: Longitudinal studies allow the modelling of disease progression through repeated measurement of health outcomes, such as biomarkers. Changes in measurement tools over time, due to logistical or financial constraints, may challenge the statistical modeling of outcome trajectories. This study aims to …
fr
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Accès ouvert
2025
erratum
OpenAlex
Gennaro Pagano, Dylan Trundell, Tanya Simuni, Nicola Pavese et autres
Correction to : npj Parkinson’s Disease (2025) 11 :193; https://doi.org/10.1038/s41531-025-01041-9 ; published online 01 July 2025
ch, gb, us, ca, de, fr, es, at
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Accès ouvert
2025
article
OpenAlex
Kirsten I. Taylor, Florian Lipsmeier, Marzia A. Scelsi, Ekaterina Volkova-Volkmar et autres
Digital health technology (DHT) tools for Parkinson's disease (PD) e.g., smartphones and wearables were used for remote and frequent measurement of motor signs in the phase 2 PASADENA study of the anti-alpha-synuclein monoclonal antibody prasinezumab. 316 early-stage PD participants were randomized to …
ch, gb, fr, us, ca, de, es, at
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Accès ouvert
2025
article
OpenAlex
Vincent Bouteloup, Nicolas Villain, Jean‐Sébastien Vidal, Fernando González‐Ortiz et autres
Importance: Blood phosphorylated tau 217 (p-tau217) showed good performance in predicting brain amyloidosis. However, the importance of detailed cognitive phenotyping in patients without dementia when interpreting p-tau217 results remains unclear. Objective: To assess whether accuracy, negative predictive value (NPV), and positive predictive …
fr, se
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Accès ouvert
2021
article
OpenAlex
Éric Frison, Cécile Proust‐Lima, Jean‐François Mangin, Marie‐Odile Habert et autres
ObjectiveTo assess the role of biomarkers of Alzheimer disease (AD), neurodegeneration, and small vessel disease (SVD) as mediators in the association between diabetes mellitus and cognition. MethodsThe study sample was derived from MEMENTO, a cohort of French adults recruited in memory clinics …
fr, us, ca
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Accès ouvert
2018
article
OpenAlex
Paul McNulty, Richard Pilcher, Renata Necuiniate, Alis Hughes et autres
BACKGROUND: People with Huntington's disease (HD) have been observed to have lower rates of cancers. OBJECTIVE: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. METHODS: Data were obtained from the European Huntington's disease network …
gb, at, de, fr, be, cz, dk, ax, se, fi
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2016
article
OpenAlex
Esther Cubo, María A. Ramos-Arroyo, Saül Martínez‐Horta, Asunción Martínez-Descalls et autres
OBJECTIVE: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. METHODS: We assessed a …
es
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