African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer
Z. Kote-Jarai, The PRACTICAL Consortium, Anders Martin Dale, G. Petrovics et autres
Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46) showed reduced performance in men with African genetic ancestry. We used a cross-validated search to identify single nucleotide polymorphisms (SNPs) that might …
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Carolina Digital Repository (University of North Carolina at Chapel Hill)