Population Pharmacokinetics of Dolutegravir in African Children: Results From the CHAPAS-4 Trial
Hylke Waalewijn, Roeland E. Wasmann, Alasdair Bamford, Diana M. Gibb et autres
We characterized population pharmacokinetics in 42 African children receiving once-daily 25 mg (14 to <20 kg) or 50 mg (>20 kg) dolutegravir. Coadministration with emtricitabine and tenofovir alafenamide reduced dolutegravir bioavailability by 19.6% (95% confidence interval: 8.13%-30.8%) compared with zidovudine or abacavir …
nl, Afrique du Sud, us, gb, Ouganda, Zambie (code pays fourni par la source)
2 citations
Journal of the Pediatric Infectious Diseases Society