Kimikazu Hamano

Frozen–thawed allogeneic fibroblast cell sheets enhance anastomotic healing in a rat colonic anastomotic leakage model

Akihiro Fujita, Koji Ueno, Yoshihiro Takemoto, Hiroshi Kurazumi et autres

Revised Abstract Background Anastomotic leakage following colorectal surgery remains a serious complication associated with peritonitis, reoperation, and prolonged hospitalization. Existing preventive strategies primarily focus on reducing perioperative risk rather than actively promoting anastomotic healing. This study examined whether the transplantation of frozen–thawed …

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Impact of a Substantial Oversizing Strategy in Chimney Endovascular Aneurysm Repair on Aortic Neck Behavior and Clinical Outcomes Compared with Open Repair for Challenging Aortic Necks

Yuriko Takeuchi, Noriyasu Morikage, Takahiro Mizoguchi, Makoto Samura et autres

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Effect of Short-Term and Long-Term Non-Physiological T3 Concentrations on Cardiac Stromal Cells: From Cellular Response to In Vivo Adaptation

Ahmad Alhamid, Yoshishige Urata, Kodai Nishi, Hiroshi Kurazumi et autres

Background/Objectives: Epidemiological and clinical studies have linked both hypothyroidism and hyperthyroidism to adverse cardiac outcomes, including heart failure and myocardial fibrosis. Triiodothyronine (T3), a biologically active thyroid hormone, is important for cardiovascular homeostasis. While the effects of physiological and non-physiological T3 levels …

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The effect of prolonged complex decongestive therapy for lower limb secondary lymphedema

Kotaro Suehiro, Takasuke Harada, Yuriko Takeuchi, Takahiro Mizoguchi et autres

OBJECTIVE: To clarify the effect of prolonged complex decongestive therapy (CDT) on limb volume in patients with lower limb lymphedema (LLL). METHODS: We reviewed patients who first visited our clinic for cancer-related LLL between April 2009 and March 2015 and continued CDT …

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miR-765 induces angiogenesis by inhibiting dipeptidyl peptidase 4 and increasing fibroblast growth factor 2

Koji Ueno, Hiroshi Kurazumi, Junichi Murakami, 溝口 貴洋 et autres

Given that extracellular vesicles (EVs) secreted from stem cells contain angiogenic microRNAs (miRNAs), these EVs show equivalent angiogenic therapeutic effect to cell transplantation. This study aimed to identify the angiogenic miRNAs from several miRNAs involved in EVs secreted from stem cells. In …

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Impact of Computed Tomography-Defined Osteopenia on Outcomes of Transcatheter Aortic Valve Implantation: A Single-Center Retrospective Study

Hiroshi Kurazumi, Ryo Suzuki, Ryosuke Nawata, Toshiki Yokoyama et autres

Background/Objectives: Transcatheter aortic valve implantation (TAVI) is a standard treatment for severe aortic stenosis, especially in older adults and high-risk patients. However, many TAVI candidates have osteopenia or osteoporosis, indicated by low bone mineral density (BMD), which is linked to frailty and …

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Postoperative pain after robotic versus VATS thymectomy: a comparative cohort study

Junichi Murakami, Toshiki Tanaka, Mototsugu Shimokawa, Sota Yoshimine et autres

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Probiotic Prophylaxis With Clostridium butyricum for Postoperative Infections Following Lung Resection: A Propensity Score–Weighted Analysis

Junichi Murakami, Toshiki Tanaka, Mototsugu Shimokawa, Sota Yoshimine et autres

BACKGROUND: This study investigated the efficacy and safety of perioperative Clostridium butyricum MIYARI 588 (CBM588) for preventing postoperative infections following thoracoscopic anatomic lung resection for primary lung cancer, with the hypothesis of a reduction in organ/space surgical site infection (OSS). Postoperative infections, …

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Anastomotic leakage prevention using dry-preserved fibroblast cell sheets in esophageal reconstruction

Hiroshi Kurazumi, Ryunosuke Sakamoto, Koji Ueno, Akihiro Fujita et autres

Background: Anastomotic leakage is a common and serious complication of esophageal reconstruction, and new methods are required for its prevention in clinical settings. We herein developed dry-preserved fibroblast cell sheets (dry sheets), which are easy to use and promote wound healing. This …

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Time-Dependent Changes in the Skin Hardness in Taxane-Induced Swollen Arms

Kotaro Suehiro, Saiko Honda, Takasuke Harada, Yuriko Takeuchi et autres

Background: We aimed to clarify the time-dependent changes in skin hardness in taxane-induced arm swelling. Methods and Results: Fifteen patients with unilateral arm swelling that developed during or within 3 months from the termination of postoperative taxane-containing chemotherapy were studied. The patients …

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A Case of G-CSF-Producing Esophageal Carcinosarcoma

Yuka SUETA, Eijiro Harada, Takayuki Kawachi, Akihiro Fujita et autres

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Bronchial Stump Coverage Using a Free Pericardial Fat Pad to Prevent Fistula Formation: A Case Report

Sota Yoshimine, Toshiki Tanaka, Junichi Murakami, Naohiro Yamamoto et autres

Bronchial stump fistulas develop into emergent and fatal conditions, so covering the bronchial stump with autologous tissues has been performed to prevent bronchial stump fistula. Covering the bronchial stump with a free pericardial fat pad is a technically simple and minimally invasive …

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