Accès ouvert
2026
article
OpenAlex
William Meurer, Sharon D. Yeatts, Romergryko G. Geocadin, Akash Roy et autres
Importance: Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective: To determine the duration of therapeutic hypothermia that maximizes neurological recovery in …
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Accès ouvert
2025
article
OpenAlex
Elizabeth Munroe, Ivan Co, Ivor S. Douglas, Robert C. Hyzy et autres
Importance: Evidence supporting the safety of infusing vasopressors through peripheral intravenous catheters (peripheral vasopressors) is largely derived from single-center studies, limiting generalizability. Objective: To evaluate factors associated with vasopressor route selection and assess safety and clinical outcomes of peripheral vasopressor administration in …
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Accès ouvert
2024
article
OpenAlex
Lorraine B. Ware, Michael S. Aboodi, Scott A. Fields, Andrea S. Foulkes et autres
Importance: Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates. Objective: To determine whether acetaminophen increases days alive and free of organ dysfunction in sepsis compared with placebo. …
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