JC Hopewell

HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease: Trial design, recruitment, and baseline characteristics

M Mafham, Mohammed Zayed, R Collins, M Sabatine et autres

BACKGROUND: Despite widespread statin use, atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Monoclonal antibodies targeting circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) substantially reduce low-density lipoprotein cholesterol (LDL-C) levels and cardiovascular events. However, the requirement for self-administration …

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MSR45 Challenges in Extrapolation When There Are Multiple Health Outcomes

C.M. Williams, NMJ Lui, Lesley A. H. Bowman, Alastair Gray et autres

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COL4A2 is associated with lacunar ischemic stroke and deep ICH

Kristiina Rannikmäe, Vhinoth Sivakumaran, Henry Millar, Rainer Malik et autres

Objective: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. Methods: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial …

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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

International Consortium for Blood Pressure Genome-Wide Associat, GB Ehret, PB Munroe, K M Rice et autres

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure …