Elena A. Mikhailova

913: LUSVERTIKIMAB, A FIRST IN CLASS IL7 RECEPTOR ANTAGONIST, IN MODERATE TO SEVERE ULCERATIVE COLITIS: RESULTS OF A MULTICCENTER RANDOMIZEDPLACEBO-CONTROLLED PHASE II STUDY

Arnaud Bourreille, Jarosław Kierkuś, Yuri Shvartz, Davit Jugheli et autres

PDGF-BB Deficiency in the Blood Serum from Aplastic Anemia Patients Affects Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells

Alena I. Dorofeeva, Irina N. Shipounova, К. А. Никифорова, Irina Vladimirovna Galtseva et autres

Aplastic anemia (AA) is characterized by bone marrow (BM) aplasia and pancytopenia. BM stromal microenvironment is closely intertwined with hematopoietic cells by reciprocal regulation. It is still unclear how hematopoietic deficiency affects the bone marrow stroma of the AA patients. Multipotent mesenchymal …

ru (code pays fourni par la source)

P767: COMPARISON OF PROLIFERATIVE, DIFFERENTIATION POTENTIAL AND GENE EXPRESSION IN MULTIPOTENT MESENCHYMAL STROMAL CELLS OF PATIENTS WITH NON-SEVERE AND SEVERE APLASTIC ANEMIA IN THE DEBUT

Alena I. Dorofeeva, Irina N. Shipounova, Anton V. Luchkin, Zalina T. Fidarova et autres

Topic: 11. Bone marrow failure syndromes incl. PNH - Biology & Translational Research Background: Aplastic anemia (AA) is a rare disease manifested in hematopoiesis disruption due to decreased number and dysfunction of hematopoietic stem cells. According to severity of pancytopenia there are …

ru (code pays fourni par la source)

Prevention of Cardiovascular Diseases in Young People

Polina Terenteva, Margarita M. Fomina, Olesya Zimoglyad, Elizaveta Korotkaya et autres

The article examines the features of prevention of cardiovascular diseases in young people. The author notes that cardiovascular diseases are among the most common diseases worldwide and cause a significant number of deaths and disabilities. According to the World Health Organization (WHO), …

METHODOLOGICAL RECOMMENDATIONS FOR THE IMPLEMENTATION OF AN APPROXIMATE ADDITIONAL PROFESSIONAL TRAINING PROGRAM FOR DOCTORS IN THE SPECIALTY "General Medicine"

Oksana M. Drapkina, S. Yu. Astanina, Diana Ildarovna Abdulganieva, R. R. Abdrakhmanov et autres

Министерство здравоохранения Российской Федерации Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр терапии и профилактической медицины» Российское общество профилактики неинфекционных заболеваний «УТВЕРЖДАЮ» академик РАН, профессор, директор ФГБУ «НМИЦ ТПМ» Минздрава России, главный внештатный специалист по терапии и общей врачебной практике Минздрава России …

METHODOLOGICAL RECOMMENDATIONS FOR THE IMPLEMENTATION OF AN APPROXIMATE ADDITIONAL PROFESSIONAL PROGRAM OF PROFESSIONAL RETRAINING OF DOCTORS IN THE SPECIALTY "General Medicine"

Oksana M. Drapkina, S. Yu. Astanina, Diana Ildarovna Abdulganieva, R. R. Abdrakhmanov et autres

Министерство здравоохранения Российской Федерации Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр терапии и профилактической медицины» Российское общество профилактики неинфекционных заболеваний «УТВЕРЖДАЮ» академик РАН, профессор, директор ФГБУ «НМИЦ ТПМ» Минздрава России, главный внештатный специалист по терапии и общей врачебной практике Минздрава России …

Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy

Jonathan Barratt, Richard A. Lafayette, Jens Halkjaer Kristensen, Andrew M. Stone et autres

The therapeutic potential of a novel, targeted-release formulation of oral budesonide (Nefecon) for the treatment of IgA nephropathy (IgAN) was first demonstrated by the phase 2b NEFIGAN trial. To verify these findings, the phase 3 NefigArd trial tested the efficacy and safety …

gb, us, se, ca, de, cz, ar, cn, tr (code pays fourni par la source)

Stromal Precursors in the Bone Marrow of Untreated Patients with Severe and Non-Severe Aplastic Anemia Differ in the Proliferative Potential

Irina N. Shipounova, A. I. Dorofeeva, Nikolay M Kapranov, Anton V. Luchkin et autres

Background. Aplastic anemia (AA) is a disorder characterized by pancytopenia, hypoplastic bone marrow (BM), and the absence of underlying malignancy. It is believed to be of autoimmune nature. However, some patients fail to respond to the immunosuppressive therapy. The impaired hematopoietic microenvironment …

ru (code pays fourni par la source)

Diagnostic significance of flow cytometry scales in diagnostics of myelodysplastic syndromes

Yulia O. Davydova, Elena Nikolaevna Parovichnikova, Irina Vladimirovna Galtseva, Alina V. Kokhno et autres

Abstract Background Myelodysplastic syndromes (MDS) can present a challenge for clinicians. Multicolor flow cytometry (MFC) can aid in establishing a diagnosis. The aim of this study was to determine the optimal MFC approach for MDS. Methods The study included 102 MDS (39 …

ru (code pays fourni par la source)

The Effects of Telmisartan and Its Combinations on Office Blood Pressure: Results of Prospective Observational Study TAINA

Ol'ga Dmitrievna Ostroumova, А. И. Кочетков, Fail T. Ageev, Г С Аникин et autres

Aim. To evaluate the effectiveness and safety of telmisartan, used in monotherapy or in combination with hydrochlorothiazide or amlodipine, in real clinical practice in patients with diagnosed arterial hypertension who have not reached the target levels of blood pressure (BP). Material and …

ru, us (code pays fourni par la source)

Эффекты телмисартана и его комбинаций на динамику офисного артериального давления: результаты проспективного наблюдательного исследования тайна

Ol'ga Dmitrievna Ostroumova, А. И. Кочетков, Fail T. Ageev, Г С Аникин et autres

Особенности субпопуляционного состава Т-клеток у пациентов с апластической анемией на разных этапах течения заболевания

А В Абрамова, Nikolay M Kapranov, Zalina T. Fidarova, Anton V. Luchkin et autres