Miodrag Grbić

Ancient whole genomes reveal regional selection during adaptation to Neolithic lifestyle in Western Eurasia

Miquel Àngel Schikora-Tamarit, Pablo Carrion, Simón Orozco-Arias, Aida Andrades Valtueña et autres

ABSTRACT The introduction of agriculture in Western Eurasia during the Mesolithic-Neolithic transition reshaped human lifestyle, demography and pathogen exposure. Yet, the associated selective pressures remain incompletely resolved because previous ancient DNA studies relied on targeted SNP panels and yielded non-overlapping results. Here, …

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The genetic characterization of grapevines prospected in old Serbian vineyards reveals multiple relationships between traditional varieties of the Balkans

Javier Tello, S. Todić, Yolanda Ferrada�s, Miroslav Nikolić et autres

Serbia preserves a high number of local grape varieties, which have been cultivated across the country for centuries. Now, these ancient varieties are in the spotlight, and there is a global trend towards their recovery and characterization because they can revitalize regional, …

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Microscopic Menaces: The Impact of Mites on Human Health

C. P. LINN, Andrea O’Malley, Kriti Khatri, Elaine M. Wright et autres

Mites are highly prevalent arthropods that infest diverse ecological niches globally. Approximately 55,000 species of mites have been identified but many more are yet to be discovered. Of the ones we do know about, most go unnoticed by humans and animals. However, …

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A genetic history of the Balkans from Roman frontier to Slavic migrations

Íñigo Olalde, Pablo J. Aguirre Carrión, Ilija Mikić, Nadin Rohland et autres

The rise and fall of the Roman Empire was a socio-political process with enormous ramifications for human history. The Middle Danube was a crucial frontier and a crossroads for population and cultural movement. Here, we present genome-wide data from 136 Balkan individuals …

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A link between energy metabolism and plant host adaptation states in the two-spotted spider mite, Tetranychus urticae (Koch)

Jorden Mikaela Maglov, Min Yi Feng, Dorothy Lin, Kennedy Barkhouse et autres

Energy metabolism is a highly conserved process that balances generation of cellular energy and maintenance of redox homeostasis. It consists of five interconnected pathways: glycolysis, tricarboxylic acid cycle, pentose phosphate, trans-sulfuration, and NAD+ biosynthesis pathways. Environmental stress rewires cellular energy metabolism. Type-2 …

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Structural and functional studies reveal the molecular basis of substrate promiscuity of a glycosyltransferase originating from a major agricultural pest

Ricardo Hernández Arriaza, Brendan Abiskaroon, Megha Patel, Leily Daneshian et autres

The two-spotted spider mite, Tetranychus urticae, is a major cosmopolitan pest that feeds on more than 1100 plant species. Its genome contains an unprecedentedly large number of genes involved in detoxifying and transporting xenobiotics, including 80 genes that code for UDP glycosyltransferases …

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Host adaptation and specialization in Tetranychidae mites

Kristie Bruinsma, Cristina Rioja, Vladimir Zhurov, M. Estrella Santamaría et autres

Composite generalist herbivores are comprised of host-adapted populations that retain the ability to shift hosts. The degree and overlap of mechanisms used by host-adapted generalist and specialist herbivores to overcome the same host plant defenses are largely unknown. Tetranychidae mites are exceptionally …

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Current status of structural studies of proteins originating from Arachnida

Safaa Kader, Ricardo Hernández Arriaza, Kriti Khatri, Andrea O’Malley et autres

Arthropods from class Arachnida constitute a large and diverse group with over 100,000 described species, and they are sources of many proteins that have a direct impact on human health. Despite the importance of Arachnida, few proteins originating from these organisms have …

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Identifying stable-against-mutations viral epitopes in SARS-CoV-2

Ildefonso M. De la Fuente, Iker Malaina, Marı́a Fedetz, M. Chruszcz et autres

Abstract We have developed a computational method “Multi-Stable Epitope Sequencer” to predict mutation-resistant regions with stability against future viral variability. At the beginning of the pandemic, this approach allowed us to identify a set of eight SARS-CoV-2 spike protein sequences that had …

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Localized efficacy of environmental RNAi in Tetranychus urticae

Nicolas Bensoussan, Maja Milojevic, Kristie Bruinsma, Sameer Dixit et autres

Environmental RNAi has been developed as a tool for reverse genetics studies and is an emerging pest control strategy. The ability of environmental RNAi to efficiently down-regulate the expression of endogenous gene targets assumes efficient uptake of dsRNA and its processing. In …

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β-Cyanoalanine synthase protects mites against Arabidopsis defenses

Sameer Dixit, Émilie Widemann, Nicolas Bensoussan, Golnaz Salehipourshirazi et autres

Glucosinolates are antiherbivory chemical defense compounds in Arabidopsis (Arabidopsis thaliana). Specialist herbivores that feed on brassicaceous plants have evolved various mechanisms aimed at preventing the formation of toxic isothiocyanates. In contrast, generalist herbivores typically detoxify isothiocyanates through glutathione conjugation upon exposure. Here, …

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Structural and functional characterization of β-cyanoalanine synthase from Tetranychus urticae

Leily Daneshian, Isabella Renggli, Ryan Hanaway, L.R. Offermann et autres

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