Hiroshi Abe

Antiviral therapies are associated with reduced mortality but under-utilized in patients with viral hepatocellular carcinoma: a multinational REAL-HCC study

Taotao Yan, Pei-Chien Tsai, Ming‐Lun Yeh, Dae Won Jun et autres

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Impact of Concurrent Steatotic Liver Disease and Chronic Hepatitis B on Treatment Response to Nucleos(t)ide Analogs

Angela Chau, Jie Li, Dae Won Jun, Yao‐Chun Hsu et autres

Data is limited regarding response to nucleos(t)ide analogs (NA) among patients with concurrent steatotic liver disease (SLD) and chronic hepatitis B (CHB). We investigated the outcomes of NA therapy between SLD-CHB and non-SLD CHB patients in a multinational CHB cohort. Adult CHB …

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Type 2 diabetes mellitus as an independent predictor of significant fibrosis in treatment-naïve chronic hepatitis B patients with concurrent hepatic steatosis

Fajuan Rui, Sally Tran, Pei‐Chien Tsai, Youwen Tan et autres

BACKGROUND AND AIMS: Type 2 diabetes mellitus (T2DM), hepatic steatosis (HS), and chronic hepatitis B (CHB) frequently co-exist, but the association of T2DM with liver histology has not been well characterized. The study investigated the impact of T2DM on the presence and …

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Beneficial effect of oral semaglutide for type 2 diabetes mellitus in patients with metabolic dysfunction‐associated steatotic liver disease: A prospective, multicentre, observational study

Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Tsunekazu Oikawa et autres

AIMS: To evaluate the efficacy and safety of oral semaglutide for type 2 diabetes mellitus (T2DM) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). MATERIALS AND METHODS: This was a single-arm, multicentre, prospective study. Among 80 consecutive patients with MASLD and …

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Author response for "Beneficial effect of oral semaglutide for type 2 diabetes mellitus in patients with metabolic dysfunction‐associated steatotic liver disease: A prospective, multicentre, observational study"

Taeang Arai, Masanori Atsukawa, Akihito Tsubota, Tsunekazu Oikawa et autres

SAT-236 Efficacy and safety of incretin-based therapies in patients with metabolic dysfunction-associated steatotic liver disease complicated by type 2 diabetes mellitus

Tadamichi Kawano, Taeang Arai, Masanori Atsukawa, Toshifumi Tada et autres

Clinical Features, Radiological Findings, and Outcome in Patients with Symptomatic Mild (<50%) Carotid Stenosis: A MUSIC Study

Daina Kashiwazaki, Kohei Chida, Kazumichi Yoshida, Kiyofumi Yamada et autres

Abstract Background and Purpose Plaque composition, but not stenosis degree, may play a key role in the development of recurrent ischemic events in patients with symptomatic, mild (<50%) carotid stenosis. This multi-center prospective cohort study was aimed to determine their clinical and …

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Mortality in patients with chronic hepatitis B treated with tenofovir or entecavir: A multinational study

Tyng‐Yuan Jang, Po‐Cheng Liang, Dae Won Jun, Jang Han Jung et autres

BACKGROUND AND AIM: The benefits of entecavir (ETV) versus tenofovir disoproxil fumarate (TDF) in reducing the development of chronic hepatitis B (CHB)-related hepatocellular carcinoma remain controversial. Whether mortality rates differ between patients with CHB treated with ETV and those treated with TDF …

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Comparison of six hepatocellular carcinoma prediction models in Japanese patients after sustained virologic response undergoing rigorous surveillance for hepatocellular carcinoma

Hidenori Toyoda, Toshifumi Tada, Haruki Uojima, Akito Nozaki et autres

BACKGROUND AND AIM: While several predictive models for the development of hepatocellular carcinoma (HCC) have been proposed, including those for patients with chronic hepatitis C virus (HCV) infection who have achieved sustained virologic response (SVR), the best model may differ between regions. …

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Antiviral Therapy Utilization and 10-Year Outcomes in Resected Hepatitis B Virus– and Hepatitis C Virus–Related Hepatocellular Carcinoma

Daniel Q. Huang, Joseph Hoang, Rubayet Kamal, Pei‐Chien Tsai et autres

PURPOSE There are limited data on antiviral treatment utilization and its impact on long-term outcomes of hepatitis B virus (HBV)– and hepatitis C virus (HCV)–related hepatocellular carcinoma (HCC) after hepatic resection. We aimed to determine the utilization and impact of antivirals in …

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Racial and ethnic disparities in untreated patients with hepatitis C virus‐related hepatocellular carcinoma but not in those with sustained virologic response

Jung Eun Park, Vy H. Nguyen, Pei‐Chien Tsai, Hidenori Toyoda et autres

BACKGROUND: Racial and ethnic disparities exist for hepatitis C virus (HCV) treatment and hepatocellular carcinoma (HCC) survival. AIM: To evaluate the impact of HCV treatment on such disparities. METHODS: In a retrospective cohort study, we analysed 6069 patients with HCV-related HCC (54.2% …

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Pretreatment gamma‐glutamyl transferase predicts mortality in patients with chronic hepatitis B treated with nucleotide/nucleoside analogs

Tyng‐Yuan Jang, Po‐Cheng Liang, Dae Won Jun, Jang Han Jung et autres

Elevated serum gamma-glutamyl transferase (GGT) levels are associated with chronic hepatitis B (CHB)-related hepatocellular carcinoma. However, their role in predicting mortality in patients with CHB treated with nucleotide/nucleoside analogs (NAs) remains elusive. Altogether, 2843 patients with CHB treated with NAs were recruited …

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