Júlio César Francisco

Comparative Evaluation of Decellularized Human Amniotic Membrane and Wharton’s Jelly in a Rat Model of Myocardial Infarction: Experimental Study

Marcos Denk, Isabella Cristina Mendes Rossa, Luize Kremer Gamba, Anna Clara Faidiga Silva et autres

Background/Objectives: Acute myocardial infarction (AMI) remains a major cause of global morbidity and mortality and is a leading factor in the development of heart failure. This study investigated the regenerative potential of decellularized human amniotic membrane (HAM) and Wharton’s jelly (WJ) in …

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Functional and Histological Analysis of Stem Cell and Amniotic Membrane Implantation After Acute Myocardial Infarction with Left Ventricular Dysfunction: Experimental Study

Isabella Cristina Mendes Rossa, Marcos Denk, Luize Kremer Gamba, Anna Clara Faidiga Silva et autres

Acute myocardial infarction (AMI) results from a lack of oxygen supply to the myocardium, leading to the loss of cardiomyocytes and their replacement with fibrotic scar tissue. This process is closely associated with the development of heart failure. Regenerative medicine has emerged …

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Tissue regeneration and drug delivery using 3D-printed alginate/graphene scaffolds

Pedro Antônio Bertelli Barbosa, Lara Namie Yamashita, Carlos de Almeida Barbosa, Vinícius Coneglian Santos et autres

The integration of graphene-based nanomaterials into alginate hydrogels has significantly advanced the design of bioactive scaffolds for tissue regeneration and localized drug delivery. Recent studies demonstrate that the combination of alginate with graphene oxide or reduced graphene oxide enhances mechanical stability, electrical …

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Aerobic and resistance training similarly enhance hippocampal BDNF expression in aged rats: implications for exercise‑induced neuroplasticity

Ricardo Corrêa Da Cunha, Fabiano Salgueirosa, Julio Cesar Bassan, Marco André Cardoso et autres

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Bovine Leukemia Virus and One Health: a Mini-Review of Emerging Evidence, Zoonotic Risks and Implications for Surveillance and Control

Rossana Baggio Simeoni, Giselle Almeida Nocera Espírito Santo, Eduardo Luis Longoria, Meila Bastos de Almeida et autres

Abstract Bovine Leukemia Virus (BLV) is a delta retrovirus widely distributed in cattle populations worldwide and is responsible for enzootic bovine leukosis, resulting in significant economic losses in the livestock industry. In recent years, increasing scientific interest has emerged regarding the potential …

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Amniotic Membrane and Stem Cells Can Improve the Immunohistochemical Profile of Achilles Tendons in Injured Rats

Rosangela Alquieri Fedato, Guilherme Vieira Cavalcante, Lúcia de Noronha, Seigo Nagashima et autres

Disorders of the Achilles tendon are common and have a major socio-economic impact. Current treatments (drugs, physiotherapy, and surgery) do not provide lasting relief, leading to chronicity and recurrence. In this context, experimental studies on regenerative therapies, such as stem cells, and …

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Amniotic Membrane and Stem Cells Improve the Immunohistochemical Profile of Injured Rat Achilles Tendons

Rosangela Alquieri Fedato, Guilherme Vieira Cavalcante, Lúcia de Noronha, Seigo Nagashima et autres

Tendon disorders are common and have a major socio-economic impact. Current treatments (drugs, physiotherapy, surgery) do not provide lasting relief, leading to chronicity and recurrence. In this context, studies on regenerative therapies, such as stem cells, platelet-rich plasma and natural and synthetic …

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Advanced 3D-Printed hydrogel dressings incorporating platelet-rich plasma for accelerated skin repair

Carlos de Almeida Barbosa, Luize Kremer Gamba, Rossana Baggio Simeoni, Maria Fernanda Villaça Kocha et autres

The restoration of cutaneous barrier function following deep skin injury remains a critical challenge in regenerative medicine. In this study, we developed a semi-occlusive wound dressing by combining sodium alginate hydrogel with platelet-rich plasma (PRP), using 3D bioprinting technology to ensure structural …

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Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats

Luize Kremer Gamba, Laiza Kremer Gamba, Camila da Costa, Aline Luri Takejima et autres

This study assessed the impact of implanting mononuclear stem cells and Wharton’s Jelly (WJ), either separately or together, on left ventricular dysfunction following myocardial infarction in Wistar rats. Functional and histopathological parameters were analyzed, and a rat model of left anterior descending …

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The effects of decellularized amniotic membrane and Wharton’s jelly on the healing of experimental skin wounds in rats

Aline Luri Takejima, Rossana Baggio Simeoni, Milka Lie TAKEJIMA, Angela Lemke et autres

Several studies have focused on novel therapeutic strategies for extensive skin lesions aiming to improve healing quality and reduce treatment duration. In this context, the use of amniotic membrane (AM) and Wharton's jelly (WJ) emerges as promising alternatives. Full-thickness dorsal skin wounds …

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Histological Alterations and Interferon-Gamma and AKT-mTOR Expression in an Experimental Model of Achilles Tendinopathy—A Comparison of Stem Cell and Amniotic Membrane Treatment

Guilherme Vieira Cavalcante, Rosangela Alquieri Fedato, Lúcia de Noronha, Seigo Nagashima et autres

Achilles tendon injuries are extremely common and have a significant impact on the physical and mental health of individuals. Both conservative and surgical treatments have unsatisfactory results. The search for new therapeutic tools, using cell therapies with stem cells (SC) and biological …

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Functional and Histological Analysis of Stem Cell and Amniotic Membrane Implantation After Acute Myocardial Infarction with Left Ventricular Dysfunction: Experimental Study

Isabella Cristina Mendes Rossa, Marcos Denk, Luize Kremer Gamba, Anna Clara Faidiga Silva et autres

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