Accès ouvert
2025
article
OpenAlex
Leah Andrews, M. Elizabeth Halloran, Lars van der Laan, Yunda Huang et autres
Importance: The test-negative design (TND) has been widely used to assess postmarketing COVID-19 vaccine effectiveness but requires further evaluation for this application. Objective: To determine whether the TND reliably evaluates vaccine effectiveness against symptomatic COVID-19 using placebo-controlled vaccine efficacy randomized clinical trials …
us, gb, be
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Leigh H. Fisher, Jia Jin Kee, Albert Liu, Claudia Espinosa et autres
Importance: SARS-CoV-2 viral load (VL) in the nasopharynx is difficult to quantify and standardize across settings, but it may inform transmission potential and disease severity. Objective: To characterize VL at COVID-19 diagnosis among previously uninfected and unvaccinated individuals by evaluating the association …
us, br, Afrique du Sud, gb, be
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Anne-Marie Rick, Matthew B. Laurens, Ying Huang, Chenchen Yu et autres
BACKGROUND: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample …
us, Afrique du Sud, br, gb, be
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Deborah Theodore, Angela R Branche, Lily Zhang, Daniel S. Graciaa et autres
Importance: Current data identifying COVID-19 risk factors lack standardized outcomes and insufficiently control for confounders. Objective: To identify risk factors associated with COVID-19, severe COVID-19, and SARS-CoV-2 infection. Design, Setting, and Participants: This secondary cross-protocol analysis included 4 multicenter, international, randomized, blinded, …
us, Afrique du Sud, br, gb, nl
(code pays fourni par la source)