Cao Liang

AAV-mediated inner ear gene delivery triggers mild host immune responses in the mammalian inner ear

Yasuko Ishibashi, Jianliang Zhu, Gwladys Gernoux, Yunkai Yu et autres

Hearing loss is a common disability affecting the world's population. Currently, its treatment options are limited. Adeno-associated virus (AAV)-mediated inner ear gene therapy has shown great promise as a treatment for hereditary hearing loss. However, the host immune responses to AAV-mediated gene …

us, fr (code pays fourni par la source)

Reviewer #2 (Public Review): Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

Zhu Jennifer, Almunif Sultan, Melissa S. Aguilar, Junzhong Wang et autres

Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies and formulations has been underexplored, and the characteristics of vaccine-induced Mtb lipid-specific memory T cells have remained elusive. Mycolic …