Louise Ma

Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis

Antoine Kimmoun, Nicolas Girerd, Kévin Duarte, Jolie Bruno et autres

PURPOSE: Red-blood-cell (RBC) transfusion is one of the most frequent interventions in critical care patients. While patients with acute cardiac conditions are more likely to receive transfusions at higher haemoglobin thresholds than other critically ill patients, data on RBC transfusion practice for …

fr, nl, cl, it, de, at, au, hr, cz, dk, gr, ec, in, Libye, pl, pt, Kenya, rs, si, es, se, ch, tr, us, gb (code pays fourni par la source)

Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan et autres

Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited.Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and …

de, nl, gb, it, es (code pays fourni par la source)

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

Joel M. Dulhunty, Stephen J. Brett, Jan J. De Waele, Dorrilyn Rajbhandari et autres

Importance: Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective: To evaluate whether continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) results in decreased all-cause mortality …

au, gb, be, nz, sg, fr (code pays fourni par la source)

Red Blood Cell Transfusion in the Intensive Care Unit

Jorinde Raasveld, Sanne de Bruin, Merijn C. Reuland, Claudia van den Oord et autres

Importance: Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little is known about how these thresholds are incorporated into current practice. Objective: To …

nl, fr, cl, us, it, de, at, au, hr, cz, dk, ec, gr, in, Libye, pl, pt, Kenya, rs, si, es, se, ch, tr, gb (code pays fourni par la source)

A second update on mapping the human genetic architecture of COVID-19

Shea J. Andrews, Mattia Cordioli, Christine Stevens, Mark J. Daly et autres

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …

us, fi, pl, my, ch, gb, Burkina Faso, ca, pr, it, in, Égypte, es, nl, Afrique du Sud, cl, hu, br, fr, be, mx, au, de, jp, py (code pays fourni par la source)

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.

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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that …

gb, cn, au, ca, ie, hk, es, mx, nl (code pays fourni par la source)

Reduction in transfer of micro-organisms between patients and staff using short-sleeved gowns and hand/arm hygiene in intensive care during the COVID-19 pandemic: A simulation-based randomised trial

Laura Vincent, Mudathir Ibrahim, Joanne Kitchin, Claire Pickering et autres

Background Current personal protective equipment (PPE) practices in UK intensive care units involve “sessional” use of long-sleeved gowns, risking nosocomial infection transmitted via gown sleeves. Data from the first wave of the COVID19 pandemic demonstrated that these changes in infection prevention and …

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Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, A. Stuckey et autres

after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …

gb, au, cn, ca, ie, us, hk, Ouganda, br (code pays fourni par la source)

125 Introducing An in situ Simulation Programme in an Intensive Care Unit

H. Bateman, Karen Johnston, Andrew Badacsonyi, Natalie Clarke et autres

This North London hospital has a 14-bed Intensive Care Unit (ICU). As a small District General ICU, staff exposure to emergency scenarios can be infrequent. Lack of practice can lead to a reduction in staff confidence and knowledge when these scenarios are …

Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

fi, us, es, de, it, gb, nl, ca, kr, jp, ae, fr, au, pl, in, be, qa, dk, cl, pr, mx (code pays fourni par la source)

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Eugenia Abaleke, Mustafa Abbas, Sadia Abbasi, Alfie Abbott et autres

BACKGROUND: Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. METHODS: In this randomised, controlled, open-label, adaptive platform …

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