Haoyu Sun

ASB2 inhibits lipid accumulation to promote ILC1 homeostatic fitness and anti-tumor immunity in the mouse liver

Boqun Bao, Xianwei Wang, Yawen Chen, Xiaodong Zheng et autres

Abstract Type 1 innate lymphoid cells (ILC1) are abundant in the adult liver and are pivotal for immune surveillance and modulation, but the regulation of their maintenance and functionality remains underexplored. Here, we re-analyze published single-cell RNA- sequencing data and find increased …

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Figure S6 from CD49a Targeting Enhances NK Cell Function and Antitumor Immunity

Yu Zhang, Yangyang Li, Z. H. Zhang, Xiaodong Zheng et autres

Inducible CD49a knockout in NK cells prevents tumor growth and prolongs survival in experimental lung metastasis model.

Supplementary Figure S1 from The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Yongjing Shi, Xiaodong Zheng, Hui Chin Peng, Chenqi Xu et autres

Supplementary Figure S1. Down regulation of FBXO38 in IT NK cells

Supplementary Figure S4 from The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Yongjing Shi, Xiaodong Zheng, Hui Chin Peng, Chenqi Xu et autres

Supplementary Figure S4. FBXO38 does not affect NK cell trafficking

Figure S2 from CD49a Targeting Enhances NK Cell Function and Antitumor Immunity

Yu Zhang, Yangyang Li, Z. H. Zhang, Xiaodong Zheng et autres

Frequencies of immune cell subsets in WT versus CD49a-KO mice.

Supplementary Figure S5 from The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Yongjing Shi, Xiaodong Zheng, Hui Chin Peng, Chenqi Xu et autres

Supplementary Figure S5. FBXO38 is positively correlated with IL2B and IL2G in human TINK cells

Figure S7 from CD49a Targeting Enhances NK Cell Function and Antitumor Immunity

Yu Zhang, Yangyang Li, Z. H. Zhang, Xiaodong Zheng et autres

Treatment with anti-CD49a mAb does not affect the body weight of the mice.

Supplementary Figure S6 from The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Yongjing Shi, Xiaodong Zheng, Hui Chin Peng, Chenqi Xu et autres

Supplementary Figure S6. FBXO38 deficiency increases the expression of suppressors of cell cycle program in TINK cells

Supplementary Figure S2 from The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Yongjing Shi, Xiaodong Zheng, Hui Chin Peng, Chenqi Xu et autres

Supplementary Figure S2. Tumor grown faster in cKO mice than Ncr1Cre/+ mice

Supplementary Figure S3 from The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Yongjing Shi, Xiaodong Zheng, Hui Chin Peng, Chenqi Xu et autres

Supplementary Figure S3. FBXO38 knockout does not affect spleen NK cell development and effector function

Figure S3 from CD49a Targeting Enhances NK Cell Function and Antitumor Immunity

Yu Zhang, Yangyang Li, Z. H. Zhang, Xiaodong Zheng et autres

CD49a deficiency prevents the exhaustion of tumor-infiltrating CD8+ T cells in experimental lung metastasis model.

Supplementary Figure S7 from The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Yongjing Shi, Xiaodong Zheng, Hui Chin Peng, Chenqi Xu et autres

Supplementary Figure S7. FBXO38 promotes human NK-92 cell proliferation in vitro